DNA methylation-mediated regulation of hypoxia-responsive genes facilitates high-altitude adaptation in Tibetan chickens

Key Points

• High-altitude adaptation is facilitated by the regulation of hypoxia-responsive genes.
• Increased DNA methylation levels were noted in Tibetan chickens, contributing to gene expression changes.
• The analysis involved detailed genetic assessment related to environmental hypoxia in Tibetan chickens.
• Findings highlight gene regulation mechanisms that may extend to other high-altitude species.