Maternal high-fat diet disrupts placental spliceosome pathways independent of obesity phenotype: time-series transcriptome analysis during mid-to-late gestation in rats

Key Points

Placental dysfunction correlates with disrupted spliceosome pathways from maternal high-fat diet.
The study identified specific time-dependent divergences in placental transcriptome dynamics during gestation.
Analysis involved time-series transcriptome analysis on placental tissues from rats fed high-fat diets.
Highlights the necessity for interventions tailored to maternal obesity phenotype and gestational stage.

Abstract

Maternal high-fat diet disrupts placental transcriptome dynamics during mid-to-late gestation, particularly affecting spliceosome pathways, regardless of maternal obesity phenotype, contributing to placental dysfunction and adverse fetal outcomes. The observed time-dependent divergences highlight the need for phenotype- and gestational stage-specific interventions to mitigate developmental risks associated with maternal HFD.

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Cite This Study

DU et al. (Sat,) studied this question.

synapsesocial.com/papers/69a75d36c6e9836116a26dbf https://doi.org/https://doi.org/10.1093/biolre/ioag023

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