Exogenous MOTS-c mitigates myocardial ischemia–reperfusion injury: experimental and in silico evidence from rat heart models | Synapse
March 3, 2026
Exogenous MOTS-c mitigates myocardial ischemia–reperfusion injury: experimental and in silico evidence from rat heart models
Key Points
Exposure to exogenous MOTS-c significantly mitigated myocardial ischemia–reperfusion injury in rat heart models, highlighting its potential for cardiac protection.
The key metric shows a marked decrease in injury markers with a 40% reduction in cell death during reperfusion phases.
Experimental and in silico analyses were conducted using rat heart models to assess the cardioprotective effects of exogenous MOTS-c.
The findings suggest exogenous MOTS-c may offer an innovative approach to mitigate damage from heart attacks, prompting further investigation.