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March 3, 2026
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Correction: Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis
ZY
Zihao Yao
WQ
Weizhong Qi
HZ
Hongbo Zhang
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Key Points
GAS6 down-regulation impairs efferocytosis, leading to increased inflammation and osteoarthritis progression.
Increased macrophage inflammation was noted alongside decreased GAS6, which may worsen outcomes in obesity-related osteoarthritis.
This observational analysis highlights a significant connection between GAS6 levels and synovial macrophage function in osteoarthritis.
Understanding GAS6's role could contribute to targeted therapies, but current findings warrant further investigation.
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Correction: Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis | Synapse
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Yao et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75d7ec6e9836116a27998
https://doi.org/https://doi.org/10.7554/elife.110769