KAT5/8-mediated GPX4 lactylation facilitates ferroptosis and inflammation in diabetic retinopathy

Key Points

• Ferroptosis occurs more significantly in diabetic retinopathy due to GPX4 lactylation.
• Analysis reveals that KAT5 and KAT8 coordinate this lactylation process, enhancing inflammation.
• Interactions within retinal cells indicate a pathway linking KAT5/8 and ferroptosis in disease progression.
• The findings highlight potential therapeutic targets to mitigate inflammation and cell death in retinopathy.