Targeting the LINC01515/miR-325-3p/ERBB4 axis suppresses gastric cancer progression | Synapse
March 3, 2026Open Access
Targeting the LINC01515/miR-325-3p/ERBB4 axis suppresses gastric cancer progression
Key Points
The LINC01515/miR-325-3p/ERBB4 axis promotes gastric cancer progression.
LINC01515 increases ERBB4 expression by sponging miR-325-3p, driving tumor growth.
Findings demonstrate the potential for therapeutic targeting of this axis in gastric cancer.
This approach may enable development of effective treatments for gastric cancer patients.
Abstract
LINC01515 upregulates ERBB4 expression in GC by sponging miR-325-3p, thereby promoting tumor growth. These findings highlight the LINC01515/miR-325-3p/ERBB4 axis as a potential therapeutic target for GC.