Platelets in the tumor microenvironment: potential mediators of immune exclusion and resistance to immune checkpoint inhibitor therapy

Key Points

• Resistance to immune checkpoint inhibitors is linked to platelet interactions within the tumor microenvironment.
• Platelets may contribute to immune exclusion, limiting T-cell access to tumors and reducing treatment effectiveness.
• Assessment reveals immune barriers created by platelets in cancers, potentially impacting therapeutic outcomes.
• Understanding these mechanisms highlights new avenues for enhancing immunotherapy strategies.