Dysregulation of Serpinb6a-Gch1 axis contributes to DFNB91 deafness that is amendable to gene therapies

Key Points

• DFNB91 deafness is linked to dysregulation of the serpinb6a-gch1 axis, impacting hearing.
• Key evidence shows that targeting this axis may allow intervention through gene therapies.
• Analysis of genetic pathways suggests that correcting the serpinb6a-gch1 dysregulation could improve hearing outcomes.
• Further investigation into this axis highlights potential strategies for treating DFNB91 deafness.