Nose-to-brain axis: mechanistic links between nasal microbiome dysbiosis, neuroinflammation, and brain disorders

Key Points

• Neuroinflammation is closely associated with dysbiosis of the nasal microbiome, leading to potential brain disorders.
• The study observes 14 relevant pathways involved in the interaction between the microbiome and brain health.
• This analysis utilizes a mechanistic framework to explore the interplay of nasal microbiome dysbiosis with neuroinflammation.
• Findings emphasize the need for further exploration of microbiome-targeted interventions in managing brain disorders.