CD4+ T cell dysregulation in major depressive disorder is associated with sleep disturbance

Key Points

• Patients with major depressive disorder and sleep disturbances show elevated CD4+ T cells compared to those without.
• The proportion of CD4+ T cells can indicate a dysregulated immune response associated with depression.
• Targeted interventions for sleep disruption may help restore immune homeostasis in these patients.
• Results suggest a novel therapeutic strategy for managing major depressive disorder through sleep improvement.