From knowledge landscapes to network mechanisms: charting regulated cell death pathways in ALS

Key Points

• Regulated cell death pathways converge around ferroptosis, inflammation, and autophagy signaling.
• Key candidate pathways and hub targets were defined for further validation and translation in ALS therapy.
• Integrated bibliometric and bioinformatics methods revealed an interconnected mechanism for cell death processes.
• This work may enable targeted interventions in ALS, addressing complex disease mechanisms with new strategies.