A porcine congenital deafness model with unconditional knockout of GJB2 generated by CRISPR/Cas9 genomic editing

Key Points

• The model exhibits congenital deafness linked to the unconditional knockout of gjb2 gene.
• In vivo examination confirmed hearing loss in the model with a 100% knockout efficiency.
• Assessment involved CRISPR/Cas9 genomic editing to disrupt the gjb2 gene effectively.
• This model may enable better understanding of auditory functions and genetic contributions.