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Effect of the 4 year treatment with donepezil and choline alphoscerate on the brain of Alzheimer’s disease patients | Synapse
March 3, 2026
Effect of the 4 year treatment with donepezil and choline alphoscerate on the brain of Alzheimer’s disease patients
ET
Enea Traini
Università di Camerino
AC
Anna Carotenuto
Ospedale Antonio Cardarelli
FA
F. Amenta
Key Points
Cognitive function improved significantly after 4 years of treatment with donepezil and choline alphoscerate in Alzheimer's patients.
Key evidence indicates that subjects exhibited notable improvement in cognitive assessments measured over the treatment period.
Observational analysis across Alzheimer’s disease patients highlights the potential effect of combined therapy on brain function.
Further investigation is essential to establish long-term efficacy and safety for Alzheimer's treatments.
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Traini et al. (Mon,) studied this question.
synapsesocial.com/papers/69a75ed3c6e9836116a29c52
https://doi.org/https://doi.org/10.1016/j.jns.2025.124071