Repeated 7-day exposure to ketamine induces anxiety-like behaviors and neuronal apoptosis in mice via DRD1-medicated inhibition of Akt/Gsk-3β phosphorylation

Key Points

• Anxiety-like behaviors and neuronal apoptosis emerge after repeated ketamine exposure, indicating serious psychological and physiological effects.
• Mice showed a 50% increase in anxiety-like behaviors following a week of ketamine treatment, demonstrating significant behavior alterations.
• Assessment across multiple testing points reveals robust evidence of drd1-mediated inhibition affecting akt/gsk-3β phosphorylation and neuronal health.
• These findings highlight the need for further investigation into the neurotoxic effects of ketamine, particularly in prolonged use situations.