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Diagnostic accuracy of GFAP and S100B as blood-based biomarkers for acute stroke: A systematic review and meta-analysis | Synapse
March 3, 2026
Diagnostic accuracy of GFAP and S100B as blood-based biomarkers for acute stroke: A systematic review and meta-analysis
AK
Amit Kumar
National Institute of Technology Patna
NK
Neetika Katiyar
Post Graduate Institute of Medical Education and Research
MC
M L Charan
Post Graduate Institute of Medical Education and Research
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Key Points
GFAP and S100B biomarkers show high diagnostic accuracy for acute stroke.
The pooled sensitivity for GFAP was 0.85, while S100B had a sensitivity of 0.80.
Systematic review and meta-analysis of various studies across multiple healthcare settings uncovered these findings.
This highlights the potential for GFAP and S100B to aid in timely stroke diagnosis, though external validation is necessary.
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Kumar et al. (Mon,) studied this question.
synapsesocial.com/papers/69a75f3ec6e9836116a2a789
https://doi.org/https://doi.org/10.1016/j.jns.2025.124532
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