Dieckol, a phlorotannin from Ecklonia cava, alleviates stress hormone-induced depressive-like behaviors through glucocorticoid receptor antagonism

Key Points

• Dieckol significantly alleviates depressive-like behaviors triggered by stress hormones, highlighting its potential as a therapeutic agent.
• In particular, administration of dieckol leads to a notable reduction in stress-induced anxiety and depression markers in tested models.
• Assessment of glucocorticoid receptor antagonism reveals that dieckol acts on these receptors to mitigate stress-related effects.
• This suggests that dieckol could support mental health treatments targeting stress-induced disorders, though further studies are warranted.