Osimertinib activates TFEB to trigger hepatocyte cytoplasmic vacuolation-associated cell death

Key Points

• Hepatocyte cell death was triggered by cytoplasmic vacuolation in the presence of osimertinib.
• Activation of TFEB was significantly associated with this process, showing a clear connection.
• The approach involved examining cellular effects of osimertinib on hepatocytes and their mechanisms.
• These findings may highlight new pathways for targeted therapies in cancer treatment.