March 3, 2026Open Access

A premixed calcium hydroxylapatite/carboxymethylcellulose–hyaluronic acid hybrid filler for mid- and lower-face skin quality: retrospective outcomes and safety at 4 months

Key Points

Improvement in mid- and lower-face aging severity observed in all Merz domains at 4 months post-treatment.
Cheek wrinkle severity significantly decreased, with p < 0.001 indicating strong results.
A retrospective analysis of 12 women who received subdermal injections with the hybrid filler demonstrates effective outcomes.
No serious adverse events were reported, with minor bruising resolving naturally within 1–2 weeks.

Abstract

AbstractBackground Hybrid injectable approaches combining calcium hydroxylapatite/carboxymethylcellulose with hyaluronic acid gels may improve both facial contour and skin quality. Methods We retrospectively reviewed 12 women treated with a premixed hybrid filler injected in the subdermal plane across the mid- and lower-face. Outcomes were assessed at baseline and 4 months using the Merz Aesthetic Scales for mid- and lower-face aging severity, the Lemperle Wrinkle Severity Scale (cheek wrinkles), and a 5-point Global Aesthetic Improvement Scale for patient-reported "skin glow." Results All Merz domains and cheek wrinkle severity improved at 4 months (cheek wrinkles, p Conclusions In this retrospective case series, the premixed hybrid filler was well tolerated and was associated with improvement in mid- and lower-face aging severity and patient-perceived skin glow at 4 months. Level of evidence IV

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Cite This Study

Lazzarotto et al. (Thu,) studied this question.

synapsesocial.com/papers/69a75f7ec6e9836116a2ae81 https://doi.org/https://doi.org/10.1016/j.jpra.2026.01.041

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