Stool-based SDC2/SFRP2/TFPI2 methylation assay for colorectal neoplasia screening: a multicenter, case-control study

Key Points

• The methylation assay of SDC2, SFRP2, and TFPI2 surpassed traditional methods for colorectal neoplasia detection.
• It demonstrated high specificity when compared to fecal occult blood tests (FOBT) and carcinoembryonic antigen (CEA).
• Combined analysis was shown to be superior, especially for identifying colorectal cancer and adenomas.
• The assay's integration into standard screening processes may improve early detection and outcomes for colorectal neoplasia.