Beyond phosphorylating Rpb1CTD, Hrr25 and Fcp1 modulate Rpb4 phosphorylation levels to regulate gene expression

Key Points

• Rpb4 phosphorylation levels directly impact gene expression outcomes, highlighting regulation significance.
• Key mechanistic insights show how Hrr25 and Fcp1 coordinate Rpb1CTD and Rpb4 phosphorylation.
• The analysis was conducted during the FEBS Workshop 2025, emphasizing diverse gene regulatory mechanisms.
• These findings support the potential evolutionary conservation of phosphorylation pathways in eukaryotes.