Tissues Guide Dependence of Treg on the Transferrin Receptor | Synapse
March 3, 2026Open Access
Tissues Guide Dependence of Treg on the Transferrin Receptor
Key Points
A loss of the transferrin receptor leads to severe autoimmunity in Tregs, highlighting their dependence on this receptor.
The study reveals a critical link between iron intake via the transferrin receptor and Treg function in various tissues.
Observational analysis across diverse disease settings shows Tregs needing iron from the transferrin receptor, particularly in atopic dermatitis.
These findings may enable targeted therapies for autoimmune conditions rooted in Treg dysfunction.
Abstract
A loss of the transferrin receptor in Tregs causes severe autoimmunity and here we clarify how Tregs rely on this receptor for iron in specific tissues and disease settings including atopic dermatitis.