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Real World Experience of Alpha-1 Antitrypsin in Treatment-Refractory Acute Graft Versus Host Disease: High Durable Response Rate | Synapse
March 3, 2026
Real World Experience of Alpha-1 Antitrypsin in Treatment-Refractory Acute Graft Versus Host Disease: High Durable Response Rate
HC
Henry Hildorf Castellani
JC
Jean Guy Caputo
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
QZ
Qiuhong Zhao
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Key Points
High durable response rate observed in treatment-refractory acute graft versus host disease patients.
The response rate was reported to be over 70% among treated patients, demonstrating significant clinical benefits.
Observational analysis provided insights into the effectiveness of alpha-1 antitrypsin for managing this condition.
Results suggest potential for broader applications of alpha-1 antitrypsin in similar immunological disorders.
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Castellani et al. (Sun,) studied this question.
synapsesocial.com/papers/69a76029c6e9836116a2ca44
https://doi.org/https://doi.org/10.1016/j.jtct.2025.12.368