Single-cell analysis uncovers preserved prostate cancer lineages and universally altered pathways in Matrigel-free patient-derived organoids

Key Points

• Preserved prostate cancer lineages were identified in patient-derived organoids, indicating continuity in cancer progression.
• Analysis highlighted universally altered pathways that could serve as biomarkers for diagnosis and therapy.
• Single-cell analysis was employed to explore these lineages and pathways, providing insights into cancer behavior.
• These findings support the potential of patient-derived organoids for personalized treatment approaches in prostate cancer.