Spin-mediated and proton-coupled electron transfer boost NADH oxidase-like activity of dual-atom metallozymes

Key Points

• The study reveals a significant boost in NADH oxidase-like activity due to spin-mediated and proton-coupled electron transfer.
• Enhanced activity is measured by specific electron transfer rates under controlled experimental conditions, highlighting the effect of dual-atom metallozymes.
• Analysis employs advanced techniques to assess the interactions within the metallozymes that enable boosted electron transfer and metabolic activities.
• Results suggest potential applications in bioenergy conversion and related biochemical processes, with findings derived from laboratory experiments.