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Molecular insights of immune evasion by Orf Virus: the interaction and functional impact of viral OH1 phosphatase on STAT1 | Synapse
March 3, 2026
Molecular insights of immune evasion by Orf Virus: the interaction and functional impact of viral OH1 phosphatase on STAT1
DP
Darío Porley
NO
Natalia Olivero-Deibe
VA
Vanina Astrada
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Key Points
The interaction of Orf virus phosphatase impairs STAT1 function, leading to immune evasion.
Specific inhibitory effects on STAT1 signaling were observed, demonstrating crucial viral strategies.
Analysis of molecular interactions uncovered how viral phosphatase manipulates immune responses.
These findings highlight potential therapeutic targets against viral-induced immune evasion.
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Porley et al. (Wed,) studied this question.
synapsesocial.com/papers/69a76070c6e9836116a2d2cd
https://doi.org/https://doi.org/10.1016/j.biochi.2026.02.006