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March 3, 2026
Thyroid hormone inactivation sustains cancer stem cell maintenance and tumorigenesis in basal cell carcinoma
DG
Daniela Di Girolamo
EC
Emery Di Cicco
CM
Caterina Miro
Federico II University Hospital
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Key Points
Tumorigenesis occurs due to the maintenance of cancer stem cells influenced by thyroid hormone inactivation.
Key evidence indicates that disrupting thyroid hormone activity significantly promotes cancer stem cell longevity and proliferation.
The approach involves assessments of cellular growth in relation to hormonal changes and cancer development dynamics.
These findings highlight the potential for targeting thyroid hormone pathways in developing novel therapeutic strategies against basal cell carcinoma.
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Cite This Study
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Girolamo et al. (Sun,) studied this question.
synapsesocial.com/papers/69a7607fc6e9836116a2d4c8
https://doi.org/https://doi.org/10.1016/j.jid.2026.01.025
Thyroid hormone inactivation sustains cancer stem cell maintenance and tumorigenesis in basal cell carcinoma | Synapse