Impact of HLA Alloimmunization on Availability of HLA Matched and Mismatched Unrelated Allogeneic Hematopoietic Cell Donors for Transplantation Disproportionately Impacts Female Patients

Key Points

• HLA alloimmunization reduces the availability of matched unrelated donors, especially impacting female patients.
• Among a diverse population, only a small percentage of female patients find compatible HLA matched donors.
• Assessment of donor databases highlights trends in HLA matching rates across genders and populations.
• The findings urge further exploration of strategies to enhance donor matching, especially for women.