Pyroptosis-inducing nanomedicines: A dual-mode therapeutic framework for apoptosis-resistant lung cancer

Key Points

• Pyroptosis was effectively induced in lung cancer cells, leading to significant tumor cell death and potential treatment advances.
• The nanomedicine interventions demonstrated a marked reduction in tumor growth in various apoptosis-resistant lung cancer lines over a 14-day period.
• Assessment using dual-mode therapeutic frameworks showed improved effectiveness over traditional single-mode strategies in targeting resistant cancer.
• These findings highlight the potential of novel nanomedicines to change treatment paradigms for resistant lung cancers, warranting further investigation.