Cytokine circuitry in pancreatic cancer: Targets for overcoming immune checkpoint inhibitor resistance in PDAC

Key Points

• Immune checkpoint inhibitor resistance is influenced by cytokine pathways in pancreatic cancer.
• Cytokine interactions may play a critical role in shaping immune responses in PDAC.
• Assessment of cytokine circuitry could identify potential therapeutic targets for overcoming resistance.
• Understanding these pathways may lead to improved treatment strategies in pancreatic cancer patients.