The T-allele of rs2285666 and G-allele of rs4646188 were significantly associated with increased coronary artery disease risk in Iraqi patients with dyslipidaemia (rs2285666 OR up to 3, rs4646188 OR up to 2.71).
Case-Control (n=170)
No
Are ACE2 gene variants (rs2285666 and rs4646188) associated with increased risk of coronary artery disease in patients with dyslipidaemia?
The T-allele of rs2285666 and the G-allele of rs4646188 in the ACE2 gene are potential genetic risk factors for coronary artery disease and are associated with altered lipid profiles in Iraqi patients with dyslipidaemia.
Effect estimate: rs2285666 T-allele: OR 2.06 females (95% CI 1.06–4.00), OR 3 males (95% CI 0.96–9.39); rs4646188 G-allele: OR 2.03 females (95% CI 0.99–4.15), OR 2.71 males (95% CI 1.07–6.92) (95% CI Included in effect sizes)
p-value: p=0.032 females rs2285666; 0.05 males rs2285666; 0.05 females rs4646188; 0.038 males rs4646188
Objectives: This study aimed to investigate the association of two intronic polymorphisms of the ACE2 gene (rs2285666 and rs4646188) with coronary artery disease (CAD) in Iraqi patients with dyslipidaemia. Methods: This case-control study was conducted from March to September 2023 at the Iraqi Center of Heart Disease, Baghdad, Iraq, and included patients with CAD and dyslipidaemia. Genotyping was performed using TaqMan probes and real-time qPCR. Results: A total of 170 participants were included in this study. Demographic, echocardiographic, and lipid profile data were analysed, revealing significant differences in age, left ventricular ejection fraction %, LV systolic diameter, LV diastolic diameter and lipid parameters. The T-allele of rs2285666 was significantly associated with CAD risk in both females (odds ratio OR = 2.06, 95% confidence interval CI: 1.06–4; P = 0.032) and males (OR = 3, 95% CI: 0.96–9.39; P = 0.05). Similarly, the G-allele of rs4646188 showed a significant association in both sexes (OR = 2.03, 95% CI: 0.99–4.15; P = 0.05) and (OR = 2.71, 95% CI: 1.07–6.93; P = 0.38). The polymorphisms were also linked to dyslipidaemia, with rs2285666 (CT+TT in females; P <0.001) and rs4646188 (G-allele in males; P = 0.037) associated with elevated total cholesterol levels. reduced high-density lipoprotein levels were linked to rs2285666 (T-allele in males; P = 0.034) and rs4646188 (AG+GG; P <0.001). Increased low-density lipoprotein levels were associated with rs2285666 (CT+TT; P = 0.006 in females; T-allele; P = 0.018 in males) and rs4646188 (G-allele in males; P = 0.022). Elevated triglyceride levels were linked to rs2285666 (CT+TT; P = 0.01) and rs4646188 (AG+GG; P = 0.001) in females. Conclusion: The T-allele of rs2285666 and the G-allele of rs4646188 were identified as potential risk factors for CAD in both sexes, with their effects influenced by dyslipidaemia status.
Abdulfattah et al. (Do,) führten eine Fall-Kontroll-Studie bei irakischen Erwachsenen mit koronarer Herzkrankheit und Dyslipidämie durch, zusammen mit einer Kontrollgruppe ohne KHK oder Dyslipidämie (n=170). Die Genotypisierung der ACE2-Genvarianten rs2285666 und rs4646188 im Vergleich zur Kontrollgruppe ohne KHK oder Dyslipidämie wurde beurteilt bezüglich der Assoziation der ACE2-Genvarianten (rs2285666 und rs4646188) Allele mit dem Risiko für koronare Herzkrankheit (rs2285666 T-Allel: OR 2,06 Frauen (95% CI 1,06–4,00), OR 3 Männer (95% CI 0,96–9,39); rs4646188 G-Allel: OR 2,03 Frauen (95% CI 0,99–4,15), OR 2,71 Männer (95% CI 1,07–6,92), 95% CI in Effektstärken einbezogen, p=0,032 Frauen rs2285666; 0,05 Männer rs2285666; 0,05 Frauen rs4646188; 0,038 Männer rs4646188). Das T-Allel von rs2285666 und das G-Allel von rs4646188 waren signifikant mit einem erhöhten Risiko für koronare Herzkrankheit bei irakischen Patienten mit Dyslipidämie assoziiert (rs2285666 OR bis zu 3, rs4646188 OR bis zu 2,71).