DHODH turns cytosolic, yet cells keep growing

Key Points

• Cell growth continues even with cytosolic localization of DHODH, underscoring metabolic flexibility.
• Changes in dihydroorotate dehydrogenase localization do not inhibit cellular proliferation, indicating resilience.
• Analysis of cellular behavior revealed metabolic pathways adapting to altered DHODH positioning.
• Support for metabolic adaptability reflects broader implications for cellular responses to localization shifts.