DSN1 promotes colorectal cancer metastasis by Inhibiting FZR1-Mediated ubiquitination of c-MYC

Key Points

• Metastasis occurs due to inhibition of FZR1-mediated ubiquitination of c-MYC, revealing a critical pathway.
• Key evidence shows that elevated DSN1 expression correlates with increased metastatic activity in colorectal cancer cells.
• Analysis of molecular interactions shows DSN1 blocking FZR1, which normally tags c-MYC for degradation.
• Findings highlight the potential for targeting DSN1 to control colorectal cancer metastasis and improve treatment outcomes.