Enhanced antidiabetic efficacy of glibenclamide with pumpkin seed extract: insights from computational and in vivo profiling

Key Points

• The combination of glibenclamide and pumpkin seed extract shows significant improvement in antidiabetic efficacy.
• The study finds a 40% increase in glucose tolerance with this combination in diabetic models.
• Assessment using computational and in vivo profiling methods provides a comprehensive understanding of the interaction.
• This highlights the need for further exploration of herbal supplements in diabetes management.