Integration of TWAS with single-cell and spatial transcriptomics identifies TLR1 as a susceptibility gene and therapeutic target in the breast cancer tumor microenvironment | Synapse
March 3, 2026
Integration of TWAS with single-cell and spatial transcriptomics identifies TLR1 as a susceptibility gene and therapeutic target in the breast cancer tumor microenvironment
Key Points
TLR1 is identified as a susceptibility gene for breast cancer, implicating its role in the tumor microenvironment.
Integration of transcriptomic data shows significant correlations with TLR1 and breast cancer susceptibility.
Assessment using transcriptome-wide association studies and spatial transcriptomics highlights TLR1's importance.
Findings support TLR1's potential as a therapeutic target, warranting further research for therapeutic interventions.