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The role of IDO1-mediated Tryptophan/Kynurenine metabolism and its association with estrogen level in PTSD within SPS mouse model | Synapse
March 3, 2026
The role of IDO1-mediated Tryptophan/Kynurenine metabolism and its association with estrogen level in PTSD within SPS mouse model
LZ
Lu Zhang
Northwestern Polytechnical University
FW
Fei-hu Wang
XW
Xiumin Wang
Taizhou Central Hospital
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Key Points
IDO1-mediated metabolism of tryptophan influences neurotransmitter levels in PTSD.
Increased kynurenine levels correlate with lower estrogen levels and PTSD severity.
Analysis using a mouse model provides insights into biochemical pathways involved in PTSD.
Highlights potential for targeted interventions based on metabolic pathways and hormonal interactions.
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Zhang et al. (Tue,) studied this question.
synapsesocial.com/papers/69a761fcc6e9836116a30130
https://doi.org/https://doi.org/10.1016/j.jpsychires.2026.02.015