GLI1 Promotes Hypoxia Induced Pyroptosis of PASMCs and Aggravates Pulmonary Arterial Hypertension in Rats by Upregulating HDAC1 Expression

Key Points

• Pyroptosis is triggered in PASMCs due to elevated GLI1 levels in hypoxia, leading to cell death.
• The study reports a notable increase in HDAC1 expression linked to GLI1 during low oxygen conditions.
• Observational analysis in a rat model demonstrates the worsening of pulmonary arterial hypertension with GLI1 activation.
• These results highlight the potential for targeting GLI1 and HDAC1 in PAH therapies.