KIF20A drives epithelial cell proliferation and migration in gastric adenocarcinoma, facilitating macrophage M2 polarization and subsequent immune evasion

Key Points

• KIF20A significantly promotes epithelial cell proliferation and migration, enhancing cancer progression.
• Increased KIF20A levels correlate with M2 macrophage polarization, fostering an immunosuppressive environment.
• This mechanism underlines the role of cytokine signaling in tumor-immune interactions in gastric adenocarcinoma.
• Potential therapeutic approaches could target KIF20A to disrupt this immune evasion process.