Extracellular vesicles derived from HSCs transmitted circPVT1 to ameliorate oxidative damage to hepatocytes by targeting the miR-125b-5p/BCL2L2 signalling pathway | Synapse
March 3, 2026
Extracellular vesicles derived from HSCs transmitted circPVT1 to ameliorate oxidative damage to hepatocytes by targeting the miR-125b-5p/BCL2L2 signalling pathway
Key Points
Extracellular vesicles significantly reduce oxidative damage in hepatocytes, enhancing cell survival and function.
The pathway involving circPVT1 and miR-125b-5p/BCL2L2 plays a crucial role in this protective effect.
Research incorporates a detailed exploration of the interaction between hepatic stellate cells and hepatocytes.
Findings highlight a potential therapeutic avenue for liver diseases, pointing to the importance of intercellular communication.