Distinct serum metabolic profiles with supportive diagnostic value in differentiating tuberculosis and Mycobacterium avium complex pulmonary disease

Key Points

Alterations in sphingoid base lipids and 2-HG serve as potential biomarkers, enhancing diagnostic capabilities for tuberculosis and MAC pulmonary disease.
The discriminative potential of metabolic profiles was highlighted, showcasing significant differences between the two mycobacterial diseases.
Assessment involved identifying specific metabolites associated with tuberculosis and MAC pulmonary disease, enabling clearer differentiation.
These findings indicate that specific serum metabolites may enable earlier diagnosis, but further validation in clinical settings is necessary.

Abstract

This study provides a novel approach for the differential diagnosis of two major mycobacterial pulmonary diseases. The identified metabolites, particularly alterations in sphingoid base lipids and 2-HG, demonstrated robust discriminative potential. These findings support their potential role as biomarkers in clinical practice, enabling earlier and more accurate differentiation of TB and MAC-PD.

Distinct serum metabolic profiles with supportive diagnostic value in differentiating tuberculosis and Mycobacterium avium complex pulmonary disease

Key Points

Abstract

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