Sex specific effects of adoptive Tregs transfer on the brain and periphery in maternal immune activation offspring rescuing immune dysregulation

Key Points

• Adoptive Treg transfer rescues immune dysregulation in offspring of mothers exposed to immune activation, influencing brain and peripheral health.
• Key findings include significant differences based on sex, affecting immune response and overall outcomes in the offspring.
• Observational analysis across models of maternal immune activation demonstrates varied effects of Treg transfer by sex.
• Supports the development of targeted immunotherapies that consider sex differences in immune response for better maternal-offspring health.