Effects and mechanism of Bifidobacterium on intestinal inflammation resulting from deoxycholic acid-induced M1 polarization of macrophages

Key Points

• Intestinal inflammation reduction occurs when using bifidobacterium, and it targets M1 polarization of macrophages.
• The study highlights significant regulation of cholesterol metabolism pathways, impacting gut health significantly.
• Assessment using mechanisms of deoxycholic acid-induced macrophage activation provides deeper insight into inflammatory responses.
• Therapeutic implications emerge, emphasizing potential dietary strategies for managing HFD-associated colitis.