Parental HFPO-TA exposure induces intergenerational reproductive toxicity and DNA methylation alterations in zebrafish

Key Points

• Reproductive toxicity was observed in zebrafish across generations, with notable DNA methylation changes.
• A significant alteration in DNA methylation patterns was noted, indicating potential long-term effects from parental exposure.
• Analysis involved zebrafish to demonstrate the transgenerational impact of HFPO-TA exposure on reproductive health.
• Findings highlight the need for further studies on intergenerational effects of environmental pollutants.