Simultaneous detection of dopamine and uric acid in the presence of ascorbic acid using nickel manganese oxides based electrodes

Dopamine (DA) and uric acid (UA) are important biomarkers for various diseases, and the development of reliable detection platforms for their detection is of significant value. In this study, nickel manganese oxide (NMO) was synthesized via a hydrothermal method, followed by thermal treatment. The morphology, structure, and composition of the samples were systematically characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS). To enhance the electrical conductivity of the material, NMO was composited with carboxylated carbon nanotubes (CCNT) to form an NMO/CCNT composite, which was then used for the simultaneous detection of DA and UA. Among the synthesized series of materials, the sample with a nickel-to-manganese molar ratio of 1:2 (denoted as N 1 M 2 O) exhibited the best sensing performance, which was attributed to its unique bimetallic synergistic effect. In the presence of ascorbic acid, the N 1 M 2 O/CCNT electrode showed a good linear response to both DA and UA within the concentration range of 1–15 μM. Furthermore, the sensor achieved satisfactory recovery rates of 96.5–105.2% in fetal bovine serum, demonstrating its potential for practical application. • The morphology and composition of NMO were modulated by changing the molar ratio of the Ni and Mn raw materials. • The NMO/CCNT composites were used for the simultaneous detection of DA, and UA. • N1M2O exhibits excellent sensing performance due to a unique bimetal synergistic effect.