Variable clinical and hemodynamic effect of sildenafil in extreme premature infants with bronchopulmonary dysplasia-associated pulmonary hypertension

Key Points

• Sildenafil exhibits varying clinical effects in treating pulmonary hypertension, specifically among extreme premature infants.
• The clinical response included improvements in oxygenation and hemodynamic parameters, with outcomes differing widely.
• Assessment involved reviewing clinical data from infants diagnosed with bronchopulmonary dysplasia and associated pulmonary hypertension.
• These findings emphasize the need for tailored treatment approaches in this vulnerable infant population.