Gangliosides GM3 And GD3 Modulate Insulin Aggregation Pathways and Reduce Cytotoxicity Through Structural Remodeling

Key Points

• Insulin aggregation decreases cytotoxicity, primarily mediated by gangliosides GD3 and GM3, which form non-fibrillar assemblies.
• Gangliosides influence the morphology of insulin aggregates, showing a reduction in harmful effects compared to traditional fibrillar aggregates.
• Analysis shows that ganglioside-bound insulin retains its seeding ability, changing the potential pathways of aggregation.
• Findings suggest therapeutic implications for gangliosides in managing insulin aggregation pathways and associated cytotoxicity.