Microbiological analysis and whole-genome sequencing of Neisseria gonorrhoeae from the microbiological failures in the international, zoliflodacin, phase 3, clinical trial for treatment of uncomplicated urogenital gonorrhoea: a retrospective, genomic, observational study

Key Points

• Microbiological analysis identifies failures in treatment specifically linked to neisseria gonorrhoeae.
• Significant genomic variations were found which may contribute to antimicrobial resistance mechanisms.
• The observational study utilized whole-genome sequencing to assess strains from an international clinical trial.
• Findings highlight the need for new interventions to address persistent treatment issues with gonorrhoea.