Interstitial cystitis-related gene CCDC8 accelerates tumorigenesis by participating in CUL7-mediated degradation of P53 in bladder cancer

Key Points

• Tumorigenesis is accelerated by the CCDC8 gene through P53 degradation, impacting cancer progression.
• CCDC8 influences CUL7-mediated degradation of P53, a key tumor suppressor, in bladder cancer.
• Analysis shows that in bladder cancer, CCDC8 interacts with the CUL7 pathway, indicating a significant biological mechanism.
• This finding could highlight the importance of targeting CCDC8 in bladder cancer therapies to manage tumor growth.