Benzalkonium disinfectants as emerging endocrine disruptors: Inhibition of 11β-Hydroxysteroid dehydrogenase 2 in human and rat models via steric and hydrophobic mechanisms: SPR and docking and enzymatic analysis | Synapse
March 3, 2026
Benzalkonium disinfectants as emerging endocrine disruptors: Inhibition of 11β-Hydroxysteroid dehydrogenase 2 in human and rat models via steric and hydrophobic mechanisms: SPR and docking and enzymatic analysis
Key Points
Inhibition of 11β-hydroxysteroid dehydrogenase 2 occurs with benzalkonium disinfectants, underscoring potential endocrine disruption.
Surface plasmon resonance and docking analysis show that both steric and hydrophobic mechanisms contribute to the inhibition.
The analysis utilized both human and rat models to examine the effects of benzalkonium disinfectants on hormone regulation.
These findings highlight the potential risks of benzalkonium disinfectants as endocrine disruptors in both human health and environmental contexts.