March 3, 2026Brain Tumor Research and Treatment1 citationsOpen Access

Multi-Layered Dysregulation of NRCAM in Lower-Grade Gliomas: Insights From TCGA Copy Number and Epigenetic Analyses

SLSteven LehrerIcahn School of Medicine at Mount Sinai PRPeter H. RheinsteinSevern Trent (United Kingdom)

Key Points

NRCAM dysregulation significantly impacts survival rates and may be linked to patient outcomes.
Key evidence shows that both DNA methylation and copy number variations stratify patient survival.
This analysis uses TCGA data to assess genetic and epigenetic changes in gliomas, providing a comprehensive view.
Further investigation into therapeutic modulation of NRCAM could lead to new treatment strategies for gliomas.

Abstract

NRCAM is recurrently dysregulated in lower-grade gliomas through CNVs and DNA methylation, both of which stratify patient survival. Together with previously reported splicing deregulation, these data suggest that NRCAM functions as a multilayered regulator of glioma progression. NRCAM methylation may represent a potential prognostic biomarker, while therapeutic modulation of NRCAM warrants further investigation.

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