Beta-caryophyllene restores liver–brain axis integrity in thioacetamide-induced hepatic encephalopathy: Behavioral and molecular insights

Key Points

• Beta-caryophyllene restored integrity of the liver-brain axis and improved behaviors related to hepatic encephalopathy.
• The study reports significant behavioral changes in a thioacetamide rat model, along with important molecular insights.
• Assessment using behavioral tests and molecular analyses demonstrated the efficacy of beta-caryophyllene in neuroinflammation.
• Further investigation is needed to explore beta-caryophyllene's potential implications for treating hepatic encephalopathy in clinical settings.